Hereditary Disease Risk
All of Us is no longer returning research DNA results, including the Hereditary Disease Risk Report.
Between 2020 and 2024, All of Us returned research DNA results. One of these results, the Hereditary Disease Risk Report, looked at 59 genes that may increase your risk for certain health conditions.
Hereditary means something that is, or can be, passed down from biological parents to kids. Genetic variants, or differences in your DNA, can be hereditary. Some can affect your health. People who have certain genetic variants may have a higher risk of getting a disease than the average person.
If a participant told us they wanted their Hereditary Disease Risk Report, All of Us checked their DNA for the genes listed below. Certain genetic variants in these genes are associated with serious health conditions. All of these conditions have treatment or prevention options. Knowing if you are at a higher risk for these conditions can be important for your health.
It is important to remember that DNA results from All of Us are research results. Before using these results in your care, they will need to be confirmed with a clinical test.
Hereditary Disease Risk Report Gene List
- ACTA2 familial thoracic aortic aneurysm and aortic dissection a blood vessel disorder MedGen
- ACTC1 hypertrophic cardiomyopathy a heart disorder MedGen
- APC familial adenomatous polyposis some types of cancers MedGen
- APOB familial hypercholesterolemia dangerously high cholesterol MedGen
- ATP7B Wilson disease a disorder called Wilson disease MedGen
- BMPR1A juvenile polyposis syndrome some types of cancers MedGen
- BRCA1 hereditary breast and ovarian cancer syndrome some types of cancers MedGen
- BRCA2 hereditary breast and ovarian cancer syndrome some types of cancers MedGen
- CACNA1S malignant hyperthermia susceptibility a disorder called malignant hyperthermia MedGen
- COL3A1 vascular Ehlers-Danlos syndrome (EDS) a disorder called Ehlers-Danlos syndrome (EDS) MedGen
- DSC2 arrhythmogenic cardiomyopathy a heart disorder MedGen
- DSG2 arrhythmogenic cardiomyopathy a heart disorder MedGen
- DSP arrhythmogenic cardiomyopathy and dilated cardiomyopathy a heart disorder MedGen
- FBN1 Marfan syndrome a blood vessel disorder MedGen
- GLA Fabry disease a disorder called Fabry disease MedGen
- KCNH2 long QT syndrome a heart disorder MedGen
- KCNQ1 long QT syndrome a heart disorder MedGen
- LDLR familial hypercholesterolemia dangerously high cholesterol MedGen
- LMNA dilated cardiomyopathy a heart disorder MedGen
- MEN1 multiple endocrine neoplasia type 1 a disorder called multiple endocrine neoplasia (MEN1) MedGen
- MLH1 Lynch syndrome some types of cancers MedGen
- MSH2 Lynch syndrome some types of cancers MedGen
- MSH6 Lynch syndrome some types of cancers MedGen
- MUTYH MUTYH-associated polyposis some types of cancers MedGen
- MYBPC3 hypertrophic cardiomyopathy a heart disorder MedGen
- MYH11 familial thoracic aortic aneurysm and aortic dissection a blood vessel disorder MedGen
- MYH7 dilated cardiomyopathy and hypertrophic cardiomyopathy a heart disorder MedGen
- MYL2 hypertrophic cardiomyopathy a heart disorder MedGen
- MYL3 hypertrophic cardiomyopathy a heart disorder MedGen
- NF2 neurofibromatosis type 2 a disorder called neurofibromatosis MedGen
- OTC ornithine carbamoyltransferase (OTC) deficiency a disorder called ornithine carbamoyltransferase (OTC) deficiency MedGen
- PCSK9 familial hypercholesterolemia dangerously high cholesterol MedGen
- PKP2 arrhythmogenic cardiomyopathy a heart disorder MedGen
- PMS2 Lynch syndrome some types of cancers MedGen
- PRKAG2 hypertrophic cardiomyopathy a heart disorder MedGen
- PTEN PTEN hamartoma tumor syndrome some types of cancer MedGen
- RB1 retinoblastoma some types of cancer MedGen
- RET multiple endocrine neoplasia type 2 (MEN2) a disorder called multiple endocrine neoplasia (MEN2) MedGen MedGen
- RYR1 malignant hyperthermia a disorder called malignant hyperthermia MedGen
- RYR2 catecholaminergic polymorphic ventricular tachycardia a heart disorder MedGen
- SCN5A Brugada syndrome and long QT syndrome 3 a heart disorder MedGenMedGen
- SDHAF2 paragangliomas 2 some type of non-cancer growths MedGen
- SDHB paragangliomas 4 some type of non-cancer growths MedGen
- SDHC paragangliomas 3 some type of non-cancer growths MedGen
- SDHD paragangliomas 1 some type of non-cancer growths MedGen
- SMAD3 Loeys-Dietz syndrome a blood vessel disorder MedGen
- SMAD4 juvenile polyposis syndrome some types of cancers MedGen
- STK11 Peutz-Jeghers syndrome some types of cancers MedGen
- TGFBR1 Loeys-Dietz syndrome a blood vessel disorder MedGen MedGen
- TGFBR2 Loeys-Dietz syndrome a blood vessel disorder MedGenMedGen
- TMEM43 arrhythmogenic cardiomyopathy a heart disorder MedGen
- TNNI3 hypertrophic cardiomyopathy a heart disorder MedGen
- TNNT2 dilated cardiomyopathy and hypertrophic cardiomyopathy a heart disorder MedGen
- TP53 Li-Fraumeni syndrome some types of cancers MedGen
- TPM1 hypertrophic cardiomyopathy a heart disorder MedGen
- TSC1 tuberous sclerosis complex a disorder called tuberous sclerosis complex MedGen
- TSC2 tuberous sclerosis complex a disorder called tuberous sclerosis complex MedGen
- VHL von Hippel-Lindau syndrome some types of cancer MedGen
- WT1 Wilms tumor a type of cancer called Wilms tumor MedGen
with this gene
- ACTA2 familial thoracic aortic aneurysm and aortic dissection a blood vessel disorder MedGen
- ACTC1 hypertrophic cardiomyopathy a heart disorder MedGen
- APC familial adenomatous polyposis some types of cancers MedGen
- APOB familial hypercholesterolemia dangerously high cholesterol MedGen
- ATP7B Wilson disease a disorder called Wilson disease MedGen
- BMPR1A juvenile polyposis syndrome some types of cancers MedGen
- BRCA1 hereditary breast and ovarian cancer syndrome some types of cancers MedGen
- BRCA2 hereditary breast and ovarian cancer syndrome some types of cancers MedGen
- CACNA1S malignant hyperthermia susceptibility a disorder called malignant hyperthermia MedGen
- COL3A1 vascular Ehlers-Danlos syndrome (EDS) a disorder called Ehlers-Danlos syndrome (EDS) MedGen
- DSC2 arrhythmogenic cardiomyopathy a heart disorder MedGen
- DSG2 arrhythmogenic cardiomyopathy a heart disorder MedGen
- DSP arrhythmogenic cardiomyopathy and dilated cardiomyopathy a heart disorder MedGen
- FBN1 Marfan syndrome a blood vessel disorder MedGen
- GLA Fabry disease a disorder called Fabry disease MedGen
- KCNH2 long QT syndrome a heart disorder MedGen
- KCNQ1 long QT syndrome a heart disorder MedGen
- LDLR familial hypercholesterolemia dangerously high cholesterol MedGen
- LMNA dilated cardiomyopathy a heart disorder MedGen
- MEN1 multiple endocrine neoplasia type 1 a disorder called multiple endocrine neoplasia (MEN1) MedGen
- MLH1 Lynch syndrome some types of cancers MedGen
- MSH2 Lynch syndrome some types of cancers MedGen
- MSH6 Lynch syndrome some types of cancers MedGen
- MUTYH MUTYH-associated polyposis some types of cancers MedGen
- MYBPC3 hypertrophic cardiomyopathy a heart disorder MedGen
- MYH11 familial thoracic aortic aneurysm and aortic dissection a blood vessel disorder MedGen
- MYH7 dilated cardiomyopathy and hypertrophic cardiomyopathy a heart disorder MedGen
- MYL2 hypertrophic cardiomyopathy a heart disorder MedGen
- MYL3 hypertrophic cardiomyopathy a heart disorder MedGen
- NF2 neurofibromatosis type 2 a disorder called neurofibromatosis MedGen
- OTC ornithine carbamoyltransferase (OTC) deficiency a disorder called ornithine carbamoyltransferase (OTC) deficiency MedGen
- PCSK9 familial hypercholesterolemia dangerously high cholesterol MedGen
- PKP2 arrhythmogenic cardiomyopathy a heart disorder MedGen
- PMS2 Lynch syndrome some types of cancers MedGen
- PRKAG2 hypertrophic cardiomyopathy a heart disorder MedGen
- PTEN PTEN hamartoma tumor syndrome some types of cancer MedGen
- RB1 retinoblastoma some types of cancer MedGen
- RET multiple endocrine neoplasia type 2 (MEN2) a disorder called multiple endocrine neoplasia (MEN2) MedGen MedGen
- RYR1 malignant hyperthermia a disorder called malignant hyperthermia MedGen
- RYR2 catecholaminergic polymorphic ventricular tachycardia a heart disorder MedGen
- SCN5A Brugada syndrome and long QT syndrome 3 a heart disorder MedGenMedGen
- SDHAF2 paragangliomas 2 some type of non-cancer growths MedGen
- SDHB paragangliomas 4 some type of non-cancer growths MedGen
- SDHC paragangliomas 3 some type of non-cancer growths MedGen
- SDHD paragangliomas 1 some type of non-cancer growths MedGen
- SMAD3 Loeys-Dietz syndrome a blood vessel disorder MedGen
- SMAD4 juvenile polyposis syndrome some types of cancers MedGen
- STK11 Peutz-Jeghers syndrome some types of cancers MedGen
- TGFBR1 Loeys-Dietz syndrome a blood vessel disorder MedGen MedGen
- TGFBR2 Loeys-Dietz syndrome a blood vessel disorder MedGenMedGen
- TMEM43 arrhythmogenic cardiomyopathy a heart disorder MedGen
- TNNI3 hypertrophic cardiomyopathy a heart disorder MedGen
- TNNT2 dilated cardiomyopathy and hypertrophic cardiomyopathy a heart disorder MedGen
- TP53 Li-Fraumeni syndrome some types of cancers MedGen
- TPM1 hypertrophic cardiomyopathy a heart disorder MedGen
- TSC1 tuberous sclerosis complex a disorder called tuberous sclerosis complex MedGen
- TSC2 tuberous sclerosis complex a disorder called tuberous sclerosis complex MedGen
- VHL von Hippel-Lindau syndrome some types of cancer MedGen
- WT1 Wilms tumor a type of cancer called Wilms tumor MedGen
- ACTA2 familial thoracic aortic aneurysm and aortic dissection a blood vessel disorder MedGen
- ACTC1 hypertrophic cardiomyopathy a heart disorder MedGen
- APC familial adenomatous polyposis some types of cancers MedGen
- APOB familial hypercholesterolemia dangerously high cholesterol MedGen
- ATP7B Wilson disease a disorder called Wilson disease MedGen
- BMPR1A juvenile polyposis syndrome some types of cancers MedGen
- BRCA1 hereditary breast and ovarian cancer syndrome some types of cancers MedGen
- BRCA2 hereditary breast and ovarian cancer syndrome some types of cancers MedGen
- CACNA1S malignant hyperthermia susceptibility a disorder called malignant hyperthermia MedGen
- COL3A1 vascular Ehlers-Danlos syndrome (EDS) a disorder called Ehlers-Danlos syndrome (EDS) MedGen
- DSC2 arrhythmogenic cardiomyopathy a heart disorder MedGen
- DSG2 arrhythmogenic cardiomyopathy a heart disorder MedGen
- DSP arrhythmogenic cardiomyopathy and dilated cardiomyopathy a heart disorder MedGen
- FBN1 Marfan syndrome a blood vessel disorder MedGen
- GLA Fabry disease a disorder called Fabry disease MedGen
- KCNH2 long QT syndrome a heart disorder MedGen
- KCNQ1 long QT syndrome a heart disorder MedGen
- LDLR familial hypercholesterolemia dangerously high cholesterol MedGen
- LMNA dilated cardiomyopathy a heart disorder MedGen
- MEN1 multiple endocrine neoplasia type 1 a disorder called multiple endocrine neoplasia (MEN1) MedGen
- MLH1 Lynch syndrome some types of cancers MedGen
- MSH2 Lynch syndrome some types of cancers MedGen
- MSH6 Lynch syndrome some types of cancers MedGen
- MUTYH MUTYH-associated polyposis some types of cancers MedGen
- MYBPC3 hypertrophic cardiomyopathy a heart disorder MedGen
- MYH11 familial thoracic aortic aneurysm and aortic dissection a blood vessel disorder MedGen
- MYH7 dilated cardiomyopathy and hypertrophic cardiomyopathy a heart disorder MedGen
- MYL2 hypertrophic cardiomyopathy a heart disorder MedGen
- MYL3 hypertrophic cardiomyopathy a heart disorder MedGen
- NF2 neurofibromatosis type 2 a disorder called neurofibromatosis MedGen
- OTC ornithine carbamoyltransferase (OTC) deficiency a disorder called ornithine carbamoyltransferase (OTC) deficiency MedGen
- PCSK9 familial hypercholesterolemia dangerously high cholesterol MedGen
- PKP2 arrhythmogenic cardiomyopathy a heart disorder MedGen
- PMS2 Lynch syndrome some types of cancers MedGen
- PRKAG2 hypertrophic cardiomyopathy a heart disorder MedGen
- PTEN PTEN hamartoma tumor syndrome some types of cancer MedGen
- RB1 retinoblastoma some types of cancer MedGen
- RET multiple endocrine neoplasia type 2 (MEN2) a disorder called multiple endocrine neoplasia (MEN2) MedGen MedGen
- RYR1 malignant hyperthermia a disorder called malignant hyperthermia MedGen
- RYR2 catecholaminergic polymorphic ventricular tachycardia a heart disorder MedGen
- SCN5A Brugada syndrome and long QT syndrome 3 a heart disorder MedGenMedGen
- SDHAF2 paragangliomas 2 some type of non-cancer growths MedGen
- SDHB paragangliomas 4 some type of non-cancer growths MedGen
- SDHC paragangliomas 3 some type of non-cancer growths MedGen
- SDHD paragangliomas 1 some type of non-cancer growths MedGen
- SMAD3 Loeys-Dietz syndrome a blood vessel disorder MedGen
- SMAD4 juvenile polyposis syndrome some types of cancers MedGen
- STK11 Peutz-Jeghers syndrome some types of cancers MedGen
- TGFBR1 Loeys-Dietz syndrome a blood vessel disorder MedGen MedGen
- TGFBR2 Loeys-Dietz syndrome a blood vessel disorder MedGenMedGen
- TMEM43 arrhythmogenic cardiomyopathy a heart disorder MedGen
- TNNI3 hypertrophic cardiomyopathy a heart disorder MedGen
- TNNT2 dilated cardiomyopathy and hypertrophic cardiomyopathy a heart disorder MedGen
- TP53 Li-Fraumeni syndrome some types of cancers MedGen
- TPM1 hypertrophic cardiomyopathy a heart disorder MedGen
- TSC1 tuberous sclerosis complex a disorder called tuberous sclerosis complex MedGen
- TSC2 tuberous sclerosis complex a disorder called tuberous sclerosis complex MedGen
- VHL von Hippel-Lindau syndrome some types of cancer MedGen
- WT1 Wilms tumor a type of cancer called Wilms tumor MedGen
additional information
- ACTA2 familial thoracic aortic aneurysm and aortic dissection a blood vessel disorder MedGen
- ACTC1 hypertrophic cardiomyopathy a heart disorder MedGen
- APC familial adenomatous polyposis some types of cancers MedGen
- APOB familial hypercholesterolemia dangerously high cholesterol MedGen
- ATP7B Wilson disease a disorder called Wilson disease MedGen
- BMPR1A juvenile polyposis syndrome some types of cancers MedGen
- BRCA1 hereditary breast and ovarian cancer syndrome some types of cancers MedGen
- BRCA2 hereditary breast and ovarian cancer syndrome some types of cancers MedGen
- CACNA1S malignant hyperthermia susceptibility a disorder called malignant hyperthermia MedGen
- COL3A1 vascular Ehlers-Danlos syndrome (EDS) a disorder called Ehlers-Danlos syndrome (EDS) MedGen
- DSC2 arrhythmogenic cardiomyopathy a heart disorder MedGen
- DSG2 arrhythmogenic cardiomyopathy a heart disorder MedGen
- DSP arrhythmogenic cardiomyopathy and dilated cardiomyopathy a heart disorder MedGen
- FBN1 Marfan syndrome a blood vessel disorder MedGen
- GLA Fabry disease a disorder called Fabry disease MedGen
- KCNH2 long QT syndrome a heart disorder MedGen
- KCNQ1 long QT syndrome a heart disorder MedGen
- LDLR familial hypercholesterolemia dangerously high cholesterol MedGen
- LMNA dilated cardiomyopathy a heart disorder MedGen
- MEN1 multiple endocrine neoplasia type 1 a disorder called multiple endocrine neoplasia (MEN1) MedGen
- MLH1 Lynch syndrome some types of cancers MedGen
- MSH2 Lynch syndrome some types of cancers MedGen
- MSH6 Lynch syndrome some types of cancers MedGen
- MUTYH MUTYH-associated polyposis some types of cancers MedGen
- MYBPC3 hypertrophic cardiomyopathy a heart disorder MedGen
- MYH11 familial thoracic aortic aneurysm and aortic dissection a blood vessel disorder MedGen
- MYH7 dilated cardiomyopathy and hypertrophic cardiomyopathy a heart disorder MedGen
- MYL2 hypertrophic cardiomyopathy a heart disorder MedGen
- MYL3 hypertrophic cardiomyopathy a heart disorder MedGen
- NF2 neurofibromatosis type 2 a disorder called neurofibromatosis MedGen
- OTC ornithine carbamoyltransferase (OTC) deficiency a disorder called ornithine carbamoyltransferase (OTC) deficiency MedGen
- PCSK9 familial hypercholesterolemia dangerously high cholesterol MedGen
- PKP2 arrhythmogenic cardiomyopathy a heart disorder MedGen
- PMS2 Lynch syndrome some types of cancers MedGen
- PRKAG2 hypertrophic cardiomyopathy a heart disorder MedGen
- PTEN PTEN hamartoma tumor syndrome some types of cancer MedGen
- RB1 retinoblastoma some types of cancer MedGen
- RET multiple endocrine neoplasia type 2 (MEN2) a disorder called multiple endocrine neoplasia (MEN2) MedGen MedGen
- RYR1 malignant hyperthermia a disorder called malignant hyperthermia MedGen
- RYR2 catecholaminergic polymorphic ventricular tachycardia a heart disorder MedGen
- SCN5A Brugada syndrome and long QT syndrome 3 a heart disorder MedGenMedGen
- SDHAF2 paragangliomas 2 some type of non-cancer growths MedGen
- SDHB paragangliomas 4 some type of non-cancer growths MedGen
- SDHC paragangliomas 3 some type of non-cancer growths MedGen
- SDHD paragangliomas 1 some type of non-cancer growths MedGen
- SMAD3 Loeys-Dietz syndrome a blood vessel disorder MedGen
- SMAD4 juvenile polyposis syndrome some types of cancers MedGen
- STK11 Peutz-Jeghers syndrome some types of cancers MedGen
- TGFBR1 Loeys-Dietz syndrome a blood vessel disorder MedGen MedGen
- TGFBR2 Loeys-Dietz syndrome a blood vessel disorder MedGenMedGen
- TMEM43 arrhythmogenic cardiomyopathy a heart disorder MedGen
- TNNI3 hypertrophic cardiomyopathy a heart disorder MedGen
- TNNT2 dilated cardiomyopathy and hypertrophic cardiomyopathy a heart disorder MedGen
- TP53 Li-Fraumeni syndrome some types of cancers MedGen
- TPM1 hypertrophic cardiomyopathy a heart disorder MedGen
- TSC1 tuberous sclerosis complex a disorder called tuberous sclerosis complex MedGen
- TSC2 tuberous sclerosis complex a disorder called tuberous sclerosis complex MedGen
- VHL von Hippel-Lindau syndrome some types of cancer MedGen
- WT1 Wilms tumor a type of cancer called Wilms tumor MedGen